Our body has innate healing abilities, continually attempting to eliminate chemical toxins through enzymatic processes in the liver.
The production, use and disposal of toxic chemicals and synthetic materials have increased the risk of exposure to health threatening toxins. Casual relationships between toxic chemicals and diseases have been well established. However many patients endure chronic symptoms that are associated with exposure to toxins before advanced stages of specific diseases are realized. Thus, there is a great demand for non-invasive laboratory tests that can be timely assess chemical exposure and the capability of hepatic detoxification.
One process by which the body eliminates toxins is enzymatic detoxification in the liver. A reliable biomarker for exposure to toxic chemicals id urinary D-glucaric acid. Elevated levels of D-glucaric acid indicateinduction of cytochrome P-459 enzymeas(phase 1) as a result of exposure to many xenbiotics. (e.g. pesticides, fungicides, petrochemicals, drugs, toluene, formaldehyde, styrenes, etc.) Such exposure induce the glucuronic acid enzymatic pathway and production of D-glucaric acid, thus urinary D-glucaric acid is an indirect by-product of chemical exposure and phase 1 detoxification reactions.
It is highly recommended that a concentrated first morning urine specimen is submitted for analysis, this assessment is available through Dr. Dickson. The test does not replace comprehensive liver tests for cases of advanced liver disease.
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